A general method for making bicyclic compounds with nitrogen at a bridgehead--application to the halichlorine spiro subunit.
نویسندگان
چکیده
N-protected beta-amino aldehydes having the nitrogen in a ring are easily converted into Morita-Baylis-Hillman adducts; O-acetylation and N-deprotection result in spontaneous cyclization to bicyclic structures having nitrogen at a bridgehead.
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ورودعنوان ژورنال:
- Chemical communications
دوره 7 شماره
صفحات -
تاریخ انتشار 2005